Basic Information
VIS ID
TVIS44022852
Fusion event
HTLV-1-NRG1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
GRCh37/hg19
Start
31727729/31870213 (Hg38)
End
31727729/31870213 (Hg38)
Orient
+
Location type
Intronic
Target gene
NRG1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-125a-3p
Nearest miRNA
hsa-mir-124-1/Upstream/1912865; hsa-mir-10400/Downstream/9400835;
Nearest TSS
ENST00000518652/Upstream/229787; ENST00000523320/Downstream/301169;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/229383, chr8-CpG: 169/Downstream/677676
Upstream sequence
GGGATTATCTTCTGGTTGCTAGTCTTCCCTTAGTTTCAATGGGAAACTTATCAGACACACTTATCTTGCAGAAGCAAGATAAGAGGACAAAAGAATTTGG
Downstream sequence
AAGATCATGGTGGAATTAAAAAAAAAGGAATGTAGTCAGATGGTAAATTTAGTCTAATTATATTTAGAGATGGGTTAACATAATCAGAAGGTAAGGAACC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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