Basic Information
VIS ID
TVIS44022864
Fusion event
HTLV-1-ANK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
41644577/41787059 (Hg38)
End
41644577/41787059 (Hg38)
Orient
+
Location type
Intronic
Target gene
ANK1
miRNAs that regulate target gene
hsa-mir-513b-5p ; hsa-mir-597-5p ; hsa-mir-6747-5p ; hsa-mir-7110-5p ; hsa-mir-6842-5p ; hsa-mir-6752-5p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-206 ; hsa-mir-613 ; hsa-mir-1-3p ; hsa-mir-125b-2-3p ; hsa-mir-4457 ; hsa-mir-4802-5p ; hsa-mir-6732-5p ; hsa-mir-4665-5p ; hsa-mir-1275 ; hsa-mir-663b ; hsa-mir-5010-5p ; hsa-mir-4525 ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-625-5p ; hsa-mir-7106-5p ; hsa-mir-6825-5p ; hsa-mir-874-5p ; hsa-mir-6894-5p ; hsa-mir-8082 ; hsa-mir-4534 ; hsa-mir-3605-5p ; hsa-mir-1204 ; hsa-mir-1247-3p ; hsa-mir-5587-3p ; hsa-mir-6840-5p ; hsa-mir-2392 ; hsa-mir-1273e ; hsa-mir-4709-3p ; hsa-mir-4684-5p ; hsa-mir-4635 ; hsa-mir-942-5p ; hsa-mir-877-3p ; hsa-mir-376c-3p ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-202-3p
Nearest miRNA
hsa-mir-124-1/Upstream/126551; hsa-mir-10400/Downstream/1109138;
Nearest TSS
ENST00000518652/Upstream/80880; ENST00000521235/Downstream/10534;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/19587, chr8-CpG: 78/Downstream/10298
Upstream sequence
TGACATGTTTTCATGGTTTCCCACACACTGAAGTCAGAGTGGGTGTCCAGTGGTCATTCATTTTTCCACTCCACATGTATTTATTTAGTGCCAGAGACGT
Downstream sequence
CCCAAAGCACAGAGGGATGCCTGATGGGGGCCATGGCCTTAAGGGGACCAGAGGGTGAGGAGCTGGGAAGCTGGACTGGAGGGCAGGCCCTGGCCTGGCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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