Basic Information
VIS ID
TVIS44022874
Fusion event
HTLV-1-SPIDR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
48430087/47517525 (Hg38)
End
48430087/47517525 (Hg38)
Orient
+
Location type
Intronic
Target gene
SPIDR
miRNAs that regulate target gene
hsa-mir-5047 ; hsa-mir-1301-3p ; hsa-mir-7156-3p ; hsa-mir-197-3p ; hsa-mir-6841-3p ; hsa-mir-4691-3p ; hsa-mir-3613-3p ; hsa-mir-4282
Nearest miRNA
hsa-mir-124-1/Upstream/4621250; hsa-mir-10400/Downstream/14197263;
Nearest TSS
ENST00000518652/Upstream/77124; ENST00000518692/Downstream/136563;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/256026, chr8-CpG: 229/Downstream/219679
Upstream sequence
AGACACTGGGTGCTTGATATGAGGTGCATATCCATGGCCACAGATGTCCCTGAGGCTGCTGATCCCTGAGGGCTCAGAAAAGAGTGGGCTTCTCCCTCAT
Downstream sequence
TAGCTAGTCTGTCTACACAATATTCTGTTGATATATTTGTGTCAAATTCATTAGGTATCCAAAATGATTATGTTCATCTATCCTGATTGTAGTTTTCTCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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