Basic Information
VIS ID
TVIS44022886
Fusion event
HTLV-1-NSMAF integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
59517612/58605053 (Hg38)
End
59517612/58605053 (Hg38)
Orient
+
Location type
Intronic
Target gene
NSMAF
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-92a-3p ; hsa-mir-25-3p
Nearest miRNA
hsa-mir-124-1/Upstream/15708778; hsa-mir-10400/Downstream/3109735;
Nearest TSS
ENST00000518652/Upstream/4875; ENST00000523683/Downstream/18366;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/51509, chr8-CpG: 111/Downstream/53991
Upstream sequence
aggctggtctcgaactcctgggctcaagagattctccctcctcggcctccgaaagtgctgggattacagtcatgagccaccatgcctagccCCAAAATCC
Downstream sequence
ATTTTTAAAGATAATTCCTTTCCAGTTATCTAGCAACTTTGTAAACTAGAATAATTTAATTTAGCCTTGCAATGTAATAAAAAAACTTTGGGCTTGAACA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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