Basic Information
VIS ID
TVIS44022904
Fusion event
HTLV-1-UBE2W integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
74709438/73797203 (Hg38)
End
74709438/73797203 (Hg38)
Orient
-
Location type
Intronic
Target gene
UBE2W
miRNAs that regulate target gene
hsa-mir-142-3p ; hsa-mir-132-3p ; hsa-mir-128-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-32-5p ; hsa-mir-218-5p ; hsa-mir-382-3p ; hsa-mir-5692a ; hsa-mir-548c-3p ; hsa-mir-3185 ; hsa-mir-141-5p ; hsa-mir-5197-3p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-6888-3p ; hsa-mir-431-5p ; hsa-mir-3120-5p ; hsa-mir-4760-3p ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u
Nearest miRNA
hsa-mir-124-1/Upstream/9417946; hsa-mir-10400/Downstream/751340;
Nearest TSS
ENST00000518652/Upstream/49495; ENST00000523794/Downstream/33271;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/49610, chr8-CpG: 109/Downstream/80904
Upstream sequence
CAAGCTGCCAGTTTCAAAGAGGTGACACCTACCATGGCTAACTTCACTGGGCTTCTGAGAAATGTAAATGAGAAAGAACTATATTAGAAGAAGGTCATTT
Downstream sequence
AGTTTTCTCCTGAGAATAAAAACTATCATATAGTTTTCCAACTATCATGGAAACCCATCTCCTTGGATATCCCCAGGGACAGAAGACTAGAAAAAAAAGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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