Basic Information
VIS ID
TVIS44022906
Fusion event
HTLV-1-HNF4G integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
76320419/75408184 (Hg38)
End
76320419/75408184 (Hg38)
Orient
-
Location type
Intronic
Target gene
HNF4G
miRNAs that regulate target gene
hsa-mir-129-5p ; hsa-mir-3149 ; hsa-mir-576-5p ; hsa-mir-4263 ; hsa-mir-4799-5p ; hsa-mir-30a-5p ; hsa-mir-194-5p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-124-1/Upstream/702437; hsa-mir-10400/Downstream/1558584;
Nearest TSS
ENST00000518652/Upstream/148; ENST00000396423/Downstream/131685;
Nearest CpG islands
chr8-CpG: 91/Target, None/Upstream, None/Downstream
Nearby gene
CASC9(No orient, 129295)
Upstream sequence
CCCCTAGGCCAGGCCGTGTTGAAAGCAGATACCCCGAGGCCTCGCCCAGCCTGCGCTGGAGGGAAGAAGGCGCTGGAGGTGCGGCAGCGGGCAGTGGGGG
Downstream sequence
GACCGGGGAATTGAAAGGTGCCAGTCCTCTACCTTAGAAAagaaagaaagagagaaggagagagagagagagagagaggagagagagagagagagTTGTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate