Basic Information
VIS ID
TVIS44022927
Fusion event
HTLV-1-LOC105375653 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
97463494/96451266 (Hg38)
End
97463494/96451266 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8B
Target gene
LOC105375653
Nearest miRNA
hsa-mir-12123/Upstream/1378270; hsa-mir-10400/Downstream/1942379;
Nearest TSS
ENST00000518652/Upstream/63828; ENST00000520233/Downstream/42085;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/188727, chr8-CpG: 160/Downstream/42253
Nearby gene
SDC2(+42388) ;
Upstream sequence
TTAAAAGTAATCACAAGAGCAATTTTTTTTAAGTTTACTCTTTAACATTATTCTGTTGAGATGCCACTCACATGGCAATGTGGCAGAAAGCCACAGAGGT
Downstream sequence
CACGCACACTTCACTGCAACTTGGCTTGTTAACGAGTCACTGGAGATGAGGCAGAGGAGAGCCACATCAGTGGCTGCCCTGCGACCTTTGCCCACAGCCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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