Basic Information
VIS ID
TVIS44022931
Fusion event
HTLV-1-VPS13B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
100466417/99454189 (Hg38)
End
100466417/99454189 (Hg38)
Orient
-
Location type
Intronic
Target gene
VPS13B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-30e-5p ; hsa-mir-186-5p ; hsa-mir-3613-5p ; hsa-mir-4494 ; hsa-mir-499b-5p ; hsa-mir-4705
Nearest miRNA
hsa-mir-12123/Upstream/1060451; hsa-mir-10400/Downstream/82447;
Nearest TSS
ENST00000518652/Upstream/64573; ENST00000521559/Downstream/66710;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/440418, chr8-CpG: 35/Downstream/439240
Upstream sequence
atataattggcatcaaacagtatataactttttcatatgggattctttgacatagtaatatgcatttttgcttcttccatgtctttccatggcttgatag
Downstream sequence
cttttatttttttgagacagggtctcattctgtcacccaggctagagtgtagtggcacaatcatagctcactgcagcctcaaactcctgttctcaagtaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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