Basic Information
VIS ID
TVIS44022947
Fusion event
HTLV-1-PAPPA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
119113718/116351439 (Hg38)
End
119113718/116351439 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA9E ; FRA9B
Target gene
PAPPA
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-26b-5p ; hsa-mir-490-3p ; hsa-mir-214-3p ; hsa-mir-1273f ; hsa-mir-4708-5p ; hsa-mir-6088 ; hsa-mir-4770 ; hsa-mir-143-3p ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-5011-5p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-141-3p
Nearest miRNA
hsa-let-7a-1/Upstream/2141910; hsa-mir-12126/Downstream/3893540;
Nearest TSS
ENST00000422679/Upstream/19007; ENST00000483254/Downstream/21760;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/196543, chr9-CpG: 37/Downstream/335755
Upstream sequence
AAGGAAAGTgggaggaagcagggaagtgaagaaaggaaaggagggaagaaggaaagaagTTAAGAAGCAAACGAAGACATTGACAAcacttttataggca
Downstream sequence
cttttcataaatgttgttttatttcatcttctcagcaccctgaaaggcagaagcaattgtttgctttccacagatagaaaaattgagattTGATGGCTCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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