Basic Information
VIS ID
TVIS44022949
Fusion event
HTLV-1-TTLL11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q33.2
Reference genome
GRCh37/hg19
Start
124823184/122060905 (Hg38)
End
124823184/122060905 (Hg38)
Orient
+
Location type
Intronic
Target gene
TTLL11
miRNAs that regulate target gene
hsa-mir-6728-3p ; hsa-mir-4495 ; hsa-mir-5582-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-6873-3p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6845-3p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-6870-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-6891-3p ; hsa-mir-6072 ; hsa-mir-6849-3p ; hsa-mir-4704-3p
Nearest miRNA
hsa-let-7a-1/Upstream/1815855; hsa-mir-12126/Downstream/59177;
Nearest TSS
ENST00000422679/Upstream/97186; ENST00000418632/Downstream/31861;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/163993, chr9-CpG: 82/Downstream/31640
Upstream sequence
TTAGCTCCAACGGTCCATTTTCTTGTTGAAGAAGAACTGTATAACTATGCCCTCTTCCAGGTATTCCTGGGGTATGGGAGAAGATCAGtgtattagtttc
Downstream sequence
ctaaggctgccataacaaattaccatgaacttggtggcttaaaacagaaatttattctctcacagctctggagacccgacatccaggatcaagatgtcag
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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