Basic Information
VIS ID
TVIS44022951
Fusion event
HTLV-1-DENND1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
126333194/123570915 (Hg38)
End
126333194/123570915 (Hg38)
Orient
-
Location type
Intronic
Target gene
DENND1A
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-98-5p
Nearest miRNA
hsa-let-7a-1/Upstream/85293; hsa-mir-12126/Downstream/1121527;
Nearest TSS
ENST00000422679/Upstream/79031; ENST00000423942/Downstream/12302;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/178632, chr9-CpG: 109/Downstream/428532
Upstream sequence
CAGTTCCTACAAGCCCTGTAGAATATCTCGAGAGTCTGAGGGTTCTGGGCCTTTAAAGAAATATGGCGTGGAGAAGGCCAGGGCTTGAGATAAACATGAA
Downstream sequence
GTCTGTAAACACGCCTTTAGATCTAAAAGAAGGAGTATTCTTGCCATATTTTTCCTCCAAAATCCATAGCTAGGGAACAATGCAATATTGTCAGTGAAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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