Basic Information
VIS ID
TVIS44022955
Fusion event
HTLV-1-MVB12B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
129182313/126420034 (Hg38)
End
129182313/126420034 (Hg38)
Orient
+
Location type
Intronic
Target gene
MVB12B
miRNAs that regulate target gene
hsa-mir-877-3p ; hsa-mir-2355-3p ; hsa-mir-676-3p ; hsa-mir-5589-3p ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-5582-5p ; hsa-mir-6768-5p ; hsa-mir-8485 ; hsa-mir-6852-3p ; hsa-mir-3909 ; hsa-mir-4330 ; hsa-mir-6862-3p ; hsa-mir-6784-3p ; hsa-mir-1224-3p ; hsa-mir-500b-3p ; hsa-mir-6800-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-4789-3p
Nearest miRNA
hsa-let-7a-1/Upstream/1726236; hsa-mir-12126/Downstream/1270653;
Nearest TSS
ENST00000422679/Upstream/24394; ENST00000489570/Downstream/1820;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/81739, chr9-CpG: 41/Downstream/62424
Upstream sequence
TTTGAACCCAAGCCTCTTGTAATGGTGTTTGGCGCCCTTTCCATCTGGCCCTGCCTGCATTTCTAGCTCTGCTTCCGACGTGTGCCCTAACCCTATGGGG
Downstream sequence
AAGTGCTGGCTCTCTCTGACTCCCTGGTGGGTGCCTTTCACTGCCATAACACCTTGAGGGGTCCTGAAGCCCCGTTCCCTTTAACAGAATATATTGTTCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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