Basic Information
VIS ID
TVIS44022958
Fusion event
HTLV-1-RALGPS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
129964181/127201902 (Hg38)
End
129964181/127201902 (Hg38)
Orient
+
Location type
Intronic
Target gene
RALGPS1
miRNAs that regulate target gene
hsa-mir-377-3p ; hsa-mir-342-3p ; hsa-mir-3120-3p ; hsa-mir-8485
Nearest miRNA
hsa-let-7a-1/Upstream/2508104; hsa-mir-12126/Downstream/488785;
Nearest TSS
ENST00000422679/Upstream/79019; ENST00000467325/Downstream/8601;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/286172, chr9-CpG: 161/Downstream/22383
Upstream sequence
TGGGCCCAGAGGCCAGCACCTGCCCTGAAAGAGCTTCCCCTCCTCGGAGACCCCACGAGCTGTTCCCTGCAGATGCCGTAAGAACACAGCTTTCTCTGCA
Downstream sequence
GGCCGCACCGCTCGAGCAGACAGAGGCCGTGGAGCCAGAGCCAAGGGTGCAGGGGAGGCCTGGGCCACGCAGAGAAGTGAGGTGTGAGAGAGGAGAGGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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