Basic Information
VIS ID
TVIS44022964
Fusion event
HTLV-1-ASS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q34.11
Reference genome
GRCh37/hg19
Start
133324457/130449070 (Hg38)
End
133324457/130449070 (Hg38)
Orient
-
Location type
Intronic
Target gene
ASS1
miRNAs that regulate target gene
hsa-mir-324-5p ; hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-mir-8067 ; hsa-mir-6508-5p ; hsa-mir-3680-5p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-5680 ; hsa-mir-3941 ; hsa-mir-606 ; hsa-mir-362-3p ; hsa-mir-329-3p
Nearest miRNA
hsa-let-7a-1/Upstream/207582; hsa-mir-126/Downstream/177227;
Nearest TSS
ENST00000422679/Upstream/4078; ENST00000443588/Downstream/3153;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/3647, chr9-CpG: 16/Downstream/88433
Nearest cancer related gene
ASS1(TSG, No orient, 0)
Upstream sequence
GCCACAGGCATCTGGGAGATGGTCCCTGTTTCCATGGAGCTCATAGTGGGGGAGAGGGCAGTTAGAATACAGCATGATggccggatgtagtggcccatgc
Downstream sequence
ctggaatcccagcactttgagaggctgaggcaggcagatcgcttaagtccaggagttcgagtccagcctgggcaatgtagtgaaaccccatctctacaaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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