Basic Information
VIS ID
TVIS44022969
Fusion event
HTLV-1-RXRA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q34.2
Reference genome
GRCh37/hg19
Start
137314668/134422822 (Hg38)
End
137314668/134422822 (Hg38)
Orient
-
Location type
Intronic
Target gene
RXRA
miRNAs that regulate target gene
hsa-mir-423-3p ; hsa-mir-128-3p ; hsa-mir-574-3p ; hsa-mir-486-3p ; hsa-mir-7106-5p ; hsa-mir-4734 ; hsa-mir-4532 ; hsa-mir-596 ; hsa-mir-3940-3p ; hsa-mir-3692-3p ; hsa-mir-6817-5p ; hsa-mir-4769-3p ; hsa-mir-1976 ; hsa-mir-6747-3p ; hsa-mir-4722-3p ; hsa-mir-6727-3p ; hsa-mir-660-3p ; hsa-mir-4667-3p ; hsa-mir-4258 ; hsa-mir-2681-5p ; hsa-mir-3180-5p ; hsa-mir-7702 ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-4724-3p ; hsa-mir-488-5p ; hsa-mir-6782-3p ; hsa-mir-27a-3p
Nearest miRNA
hsa-let-7a-1/Upstream/43350; hsa-mir-126/Downstream/426476;
Nearest TSS
ENST00000422679/Upstream/50851; ENST00000444936/Downstream/82650;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/13473, chr9-CpG: 22/Downstream/16648
Upstream sequence
TTGGGGGAAGGGCCTGGGGCCTCAGTTTCCCTCCATCCCTCATAAGGAGGTGTACCATGCGGGGTCTCTCAGTGGCCTTCAGAGAGGTAATGGGCTGTCG
Downstream sequence
GTGGAGGTTTGGGGGCTCTGGAGAGGGAGGCTGGCTGTGTTCCAGGGGCTGCCCAGGAGAGCCACGTGCTCTCTGCCCTTCTCCTCCCACTCCAAGGCCG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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