Basic Information
VIS ID
TVIS44022975
Fusion event
HTLV-1-CAMSAP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q34.3
Reference genome
GRCh37/hg19
Start
138713203/135821357 (Hg38)
End
138713203/135821357 (Hg38)
Orient
+
Location type
Exonic
Target gene
CAMSAP1
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-19b-3p ; hsa-mir-16-5p ; hsa-mir-877-5p ; hsa-mir-92b-3p ; hsa-mir-4762-3p ; hsa-mir-4303 ; hsa-mir-4468 ; hsa-mir-6751-3p ; hsa-mir-1199-5p ; hsa-mir-6507-5p ; hsa-mir-497-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-6838-5p ; hsa-mir-335-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-3942-3p ; hsa-mir-548aw ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-548o-3p ; hsa-mir-1323 ; hsa-mir-455-5p ; hsa-mir-33a-3p ; hsa-mir-409-3p ; hsa-mir-5583-5p ; hsa-mir-3129-3p ; hsa-mir-19a-3p
Nearest miRNA
hsa-let-7a-1/Upstream/970550; hsa-mir-126/Downstream/698211;
Nearest TSS
ENST00000422679/Upstream/2291; ENST00000423793/Downstream/5052;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/2104, chr9-CpG: 213/Downstream/85259
Upstream sequence
GTCTCAAGTGCGGGAGCGTCTCTACACTGGGCGTTGGGGTTTTACTTCGGGAGGAGCCCTGTGGCCTGTCTTTTGGGACCTTCAGCTCCGCCGGCCTTCC
Downstream sequence
GGAACGGGAATTCCGGCCTTGACCCAGCCGGGGGGCTTTGCGGTGGCCAGCCACGCCCGTGGGAGAGAGTGGCTCCACGAAGTGGACTGGTGCCTTCACT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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