Basic Information
VIS ID
TVIS44022987
Fusion event
HTLV-1-ADAMTSL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
18600516/18600518 (Hg38)
End
18600516/18600518 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADAMTSL1
miRNAs that regulate target gene
hsa-mir-132-3p ; hsa-mir-25-3p ; hsa-mir-3202 ; hsa-mir-3689d ; hsa-mir-377-5p ; hsa-mir-4533 ; hsa-mir-6079 ; hsa-mir-6086 ; hsa-mir-6133 ; hsa-mir-6134 ; hsa-mir-6851-5p ; hsa-mir-6880-5p ; hsa-mir-6894-5p ; hsa-mir-7154-3p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-7847-3p
Nearest miRNA
hsa-mir-101-2/Upstream/27139; hsa-let-7a-1/Downstream/1810630;
Nearest TSS
ENST00000422679/Upstream/126285; ENST00000546040/Downstream/57097;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/161714, chr9-CpG: 79/Downstream/176242
Upstream sequence
tgtctgaccctatagcctgtgctttttattttactgtacTGATTCATAGAATTATACTTCCCTCCTAGACAACCCTCCCTGAATTTTAAGCCCCTGAGAA
Downstream sequence
TCTATGACTGGATACCAAGAATTGGGGTCCCTACTTGCCACTGGTTTTTGGGTTTCTATGAGAAACAGTAGAAAAGAGAAGTTCTGATTATCACTGGTGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate