Basic Information
VIS ID
TVIS44022989
Fusion event
HTLV-1-SLC24A2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
20001049/20001051 (Hg38)
End
20001049/20001051 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA9C
Target gene
SLC24A2
miRNAs that regulate target gene
hsa-mir-1277-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-6083 ; hsa-mir-4789-5p ; hsa-mir-4774-5p ; hsa-mir-4490 ; hsa-mir-340-5p ; hsa-mir-142-5p ; hsa-mir-5590-3p ; hsa-mir-4775 ; hsa-mir-29a-5p ; hsa-mir-590-3p ; hsa-mir-410-3p ; hsa-mir-4672 ; hsa-mir-6768-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-4474-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-3922-5p ; hsa-mir-3142 ; hsa-mir-1245b-5p
Nearest miRNA
hsa-mir-101-2/Upstream/1427672; hsa-let-7a-1/Downstream/410097;
Nearest TSS
ENST00000422679/Upstream/74957; ENST00000604036/Downstream/362518;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/66222, chr9-CpG: 167/Downstream/619374
Nearby gene
SLC24A2(-214032) ;
Upstream sequence
CTGACCCTAATGGATAGTAAGATGAATATTATCTTGGTATCCAAGAGCAAAGATCACGTTTTGAGGCCCTTTCTCTCCCCATCCATTGCTCTAATGGGCC
Downstream sequence
CACCCTCACTTTAAAAATAAACAATCAAATGCAAACGTGGCAGTTGCATTTTGTGGGCCACAAAGGAGAAAGTTAAAGCCTGGAGGATCAGCACTTCGTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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