Basic Information
VIS ID
TVIS44022990
Fusion event
HTLV-1-CDKN2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
21984776/21984777 (Hg38)
End
21984776/21984777 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA9C
Target gene
CDKN2A
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-let-7g-5p ; hsa-mir-125b-5p ; hsa-mir-492 ; hsa-mir-10b-5p ; hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-34a-5p ; hsa-mir-192-5p ; hsa-mir-16-5p ; hsa-mir-455-3p ; hsa-mir-423-5p ; hsa-mir-296-3p ; hsa-mir-615-3p ; hsa-mir-320a
Nearest miRNA
hsa-mir-101-2/Upstream/472592; hsa-let-7a-1/Downstream/6878849;
Nearest TSS
ENST00000422679/Upstream/9679; ENST00000645313/Downstream/9634;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/9470, chr9-CpG: 25/Downstream/4997
Nearest cancer related gene
CDKN2A(TSG, No orient, 0)
Upstream sequence
TAATATTCATGTTTCACTGATAGGTTTAACACTGGTTTAGGATACTCTAATTTCAGGGGCACCATCTACATGGAAGCTTTTCTCATCAAATGGAGAATGG
Downstream sequence
TTGTCCCCCTTTTGCCCCTCTAAAAAACTATCCTTTAAAAGTAGCTTGCTTTCTTGGGACTCTATAGTCTTACTGTTATGTTCAATTTTCTGTGTCCTTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate