Basic Information
VIS ID
TVIS44023011
Fusion event
HTLV-1-APTX integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
32977882/32977884 (Hg38)
End
32977882/32977884 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA9C
Target gene
APTX
miRNAs that regulate target gene
hsa-mir-342-3p ; hsa-mir-7977 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-5693 ; hsa-mir-6783-3p ; hsa-mir-4279 ; hsa-mir-1343-3p ; hsa-mir-377-3p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-2276-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-1281 ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-660-3p ; hsa-mir-4485-5p ; hsa-mir-1228-3p ; hsa-mir-6722-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-383-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-1304-3p ; hsa-mir-1307-3p ; hsa-mir-4638-5p ; hsa-mir-6741-3p ; hsa-mir-6890-3p ; hsa-mir-891a-3p
Nearest miRNA
hsa-mir-101-2/Upstream/4088929; hsa-let-7a-1/Downstream/130808;
Nearest TSS
ENST00000422679/Upstream/136122; ENST00000465677/Downstream/9878;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/21604, chr9-CpG: 38/Downstream/23334
Upstream sequence
tgcaccactgcactccagcctgggcaacagagtgagactctgtctcaaaaaagaaaaagaaaaaaaaaaCGGAAACAGATACCATATAATTATCATATGG
Downstream sequence
TCTCTGATATAAGAAGGTATTTAAAGAAGGGGCATTAGGTCAAAAACAAGGACTAACCCAAGTGTGTTGCTTTAAAAATCTAATTTGTAGGAAAACTAGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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