Basic Information
VIS ID
TVIS44023013
Fusion event
HTLV-1-CLTA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
36192873/36192876 (Hg38)
End
36192873/36192876 (Hg38)
Orient
-
Location type
Intronic
Target gene
CLTA
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-23b-3p ; hsa-mir-142-3p ; hsa-mir-3159 ; hsa-mir-4255 ; hsa-mir-3678-3p ; hsa-mir-4662a-3p ; hsa-mir-6073 ; hsa-mir-6869-5p ; hsa-mir-1273h-3p ; hsa-mir-7852-3p ; hsa-mir-33a-3p ; hsa-mir-653-3p ; hsa-mir-4420 ; hsa-mir-181b-3p ; hsa-mir-181b-2-3p ; hsa-mir-6837-3p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p
Nearest miRNA
hsa-mir-101-2/Upstream/459881; hsa-let-7a-1/Downstream/630663;
Nearest TSS
ENST00000422679/Upstream/1711; ENST00000489766/Downstream/56520;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/1337, chr9-CpG: 76/Downstream/65297
Upstream sequence
TACCACATTCTGTTGCAGTGTTTAGTTGTTTTAGCAGGGGTGTAGTGCGATAACAGACAGGCAGCTGTGGCTGTCCCAGGTGGAACAGATTTGGGAGAAG
Downstream sequence
CAGAACCCAAGATCTGTAGTTGGAAGATTGTCCTGATTCAAGGACAGTGTTACCCttactgttttatctccactgcctagcagtgtgtctgacatgtagt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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