Basic Information
VIS ID
TVIS44023026
Fusion event
HTLV-1-KDM4C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
6992841/6992841 (Hg38)
End
6992841/6992841 (Hg38)
Orient
+
Location type
Intronic
Target gene
KDM4C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-409-3p ; hsa-mir-432-5p
Nearest miRNA
hsa-mir-101-2/Upstream/984937; hsa-let-7a-1/Downstream/11580465;
Nearest TSS
ENST00000422679/Upstream/8560; ENST00000495890/Downstream/20947;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/233969, chr9-CpG: 43/Downstream/806514
Nearest cancer related gene
KDM4C(OG, No orient, 0)
Upstream sequence
GGGGGATTTTCTGTCCTAACTATTCTGCTCCTTTTGCACTCCTCATACGTAGGAGCATAACTATATTAGAGCATAGGAGAATTGCATCTTTAAACAACAA
Downstream sequence
TCAGTGTCTTCTGTTGGTGAACGAGCATTTCTCTATTGAAGCTGGAAAGTTTCTCCCTAACAGAAAGGCTGCACAGGGGAAAGTGACTTGGTCCAGGACC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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