Basic Information
VIS ID
TVIS44023027
Fusion event
HTLV-1-chr9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.12
Reference genome
GRCh37/hg19
Start
73149746/70534830 (Hg38)
End
73149746/70534830 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC101927086 ; TRPM3
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-4433b-5p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-6778-3p ; hsa-mir-532-3p ; hsa-mir-1281 ; hsa-mir-1224-3p ; hsa-mir-6814-5p ; hsa-mir-4761-5p
Nearest miRNA
hsa-mir-101-2/Upstream/29300995; hsa-let-7a-1/Downstream/275145;
Nearest TSS
ENST00000422679/Upstream/120206; ENST00000436491/Downstream/173217;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/114521, chr9-CpG: 50/Downstream/911767
Nearby gene
TRPM3(-220) ;
Upstream sequence
TACTTTGGAACATTTCCATAGAAAAGATACCAGCCCTTGAAAAACTCCAATTAAATTTATGCTGAGCTCAGATTAGATGGCAAAACTCTAGGTATGAAAA
Downstream sequence
TATCCACATATAACCATATATTCATATACAAAATGGTCATGTGATGAGTGGTGTGAAAAATTGGCAGTTACGTCTTGGAGGTGTTCAGGAGGACGTGGTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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