Basic Information
VIS ID
TVIS44023037
Fusion event
HTLV-1-NTRK2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
87511719/84896804 (Hg38)
End
87511719/84896804 (Hg38)
Orient
-
Location type
Intronic
Target gene
NTRK2
miRNAs that regulate target gene
hsa-mir-200c-3p ; hsa-mir-335-5p ; hsa-mir-204-5p ; hsa-mir-581 ; hsa-mir-145-3p ; hsa-mir-22-3p
Nearest miRNA
hsa-mir-101-2/Upstream/926947; hsa-let-7a-1/Downstream/3849032;
Nearest TSS
ENST00000422679/Upstream/226144; ENST00000416045/Downstream/682221;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/226015, chr9-CpG: 42/Downstream/625890
Upstream sequence
CTCGTACCATATGCTTTAGGAGGGATTAAACTTTAATAGTGAGATATTCTAAAGCCCTGTCAGGACATCTCCACAAAATGCTTGTTCTTCTGCCTCTCCC
Downstream sequence
TAGGAGTGGCTCCTGATAAGAGGAATGGTGAGGATGAGGATGAAGACCAGGACGAATGAGAGTAAATGGGGAAGCCCGTGGCAGTAGCTGAGAGTTAGGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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