Basic Information
VIS ID
TVIS44023045
Fusion event
HTLV-1-SEMA4D integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
91992781/89377866 (Hg38)
End
91992781/89377866 (Hg38)
Orient
-
Location type
UTR3
Target gene
SEMA4D
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-335-5p ; hsa-mir-1-3p ; hsa-mir-215-5p ; hsa-mir-484 ; hsa-mir-25-3p ; hsa-mir-218-5p ; hsa-mir-3679-3p ; hsa-mir-5681a ; hsa-mir-361-3p ; hsa-mir-4286 ; hsa-mir-4301 ; hsa-mir-5088-5p ; hsa-mir-7844-5p ; hsa-mir-3662 ; hsa-mir-1225-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-3973 ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-7849-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-214-3p
Nearest miRNA
hsa-mir-101-2/Upstream/65560; hsa-let-7a-1/Downstream/645575;
Nearest TSS
ENST00000422679/Upstream/584; ENST00000494726/Downstream/3321;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/58874, chr9-CpG: 21/Downstream/3170
Upstream sequence
TGTACCGCACTCCCATCTCAGCTCTGGGCCAGCCTGGCTCCACTCAGCTCATCCAGGCTACCTTCCCTTGCTCAAAACCCACCTCGTGGATGTGGGAAGG
Downstream sequence
TCCTCTTCTTCGAGAGAGTAAAAGTTAAAAAAAAAGAAAAGTAAAACGAAGTACAGAAAGAAAATCTCTCCAAAAACAATGCTTCCCTCAAGGAATAAAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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