Basic Information
VIS ID
TVIS44023064
Fusion event
HTLV-1-PDCD11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
105188558/103428801 (Hg38)
End
105188558/103428801 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
PDCD11
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-let-7b-5p ; hsa-mir-320b ; hsa-mir-361-3p ; hsa-mir-615-3p ; hsa-mir-17-3p ; hsa-let-7e-5p ; hsa-mir-4286 ; hsa-mir-335-3p ; hsa-mir-4793-5p ; hsa-mir-5196-3p ; hsa-mir-6873-5p ; hsa-mir-216a-5p ; hsa-mir-548c-3p
Nearest miRNA
hsa-mir-107/Upstream/34400; hsa-mir-202/Downstream/619288;
Nearest TSS
ENST00000439456/Upstream/3817; ENST00000466959/Downstream/5192;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/32074, chr10-CpG: 31/Downstream/23392
Upstream sequence
AATGGTTTTTGATCCTAGGAGTACTGAGGAACCCCTCATTAACACTGCTGGTGTTGGAAGACTATGGTATGAGCCAGAGTGGGGGTACTTGGCTGTAGCA
Downstream sequence
GAGTGGGCCATGACAGGAATTGAGTGGATTTGTTAAGGAGGTGGGAGATGTAGAGTTATAATAACAGATAGACAGATGGCCAGACACACTCCCAGACAGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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