Basic Information
VIS ID
TVIS44023071
Fusion event
HTLV-1-MXI1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
111976011/110216253 (Hg38)
End
111976011/110216253 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
MXI1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-106b-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-769-3p ; hsa-mir-615-3p ; hsa-mir-30c-5p ; hsa-mir-24-3p ; hsa-mir-27a-5p ; hsa-mir-155-5p ; hsa-mir-20a-5p ; hsa-mir-1273e ; hsa-mir-4722-5p ; hsa-mir-1827 ; hsa-mir-219b-3p ; hsa-mir-4768-3p ; hsa-mir-940 ; hsa-mir-6808-5p ; hsa-mir-6893-5p ; hsa-mir-302f ; hsa-mir-6715b-3p ; hsa-mir-676-5p ; hsa-mir-342-3p ; hsa-mir-216b-3p ; hsa-mir-548g-3p ; hsa-mir-7847-3p ; hsa-mir-6880-5p ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-6499-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-4775 ; hsa-mir-4735-5p ; hsa-mir-590-3p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p ; hsa-mir-493-3p ; hsa-mir-4537
Nearest miRNA
hsa-mir-107/Upstream/5947848; hsa-mir-202/Downstream/681837;
Nearest TSS
ENST00000439456/Upstream/6022; ENST00000442296/Downstream/9740;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/5288, chr10-CpG: 200/Downstream/9552
Nearest cancer related gene
MXI1(TSG, No orient, 0)
Upstream sequence
ATGTTTTGAAAGTTCAGGTGACCCTTGGTTTGAGCAGTACGCTCCAGGGAATATATGTAAACAGAATCCTTTTTCAAAAAAATTTAGAGAAACTCTCTTG
Downstream sequence
AAAAGCCCTTGTGGCAACTATTTTGGTAAGATGTGGAATTATGTTGTGAGCCATTCTCCCTAAATTTGTGTTTATTCattcattaattaaaccagtacat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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