Basic Information
VIS ID
TVIS44023072
Fusion event
HTLV-1-WDR37 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p15.3
Reference genome
GRCh37/hg19
Start
1151036/1105096 (Hg38)
End
1151036/1105096 (Hg38)
Orient
-
Location type
Intronic
Target gene
WDR37
miRNAs that regulate target gene
hsa-mir-429 ; hsa-mir-200a-3p ; hsa-mir-200c-3p ; hsa-mir-141-3p ; hsa-mir-200b-3p ; hsa-mir-744-5p ; hsa-mir-30b-5p ; hsa-mir-92a-3p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-362-3p ; hsa-mir-8485 ; hsa-mir-329-3p ; hsa-mir-8064 ; hsa-mir-6729-3p ; hsa-mir-6767-3p ; hsa-mir-3655 ; hsa-mir-4662a-5p ; hsa-mir-449b-3p ; hsa-mir-32-3p ; hsa-mir-642a-5p ; hsa-mir-4777-3p ; hsa-mir-642b-5p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-4667-3p ; hsa-mir-1470
Nearest miRNA
hsa-mir-5699/Upstream/463318; hsa-mir-107/Downstream/970923;
Nearest TSS
ENST00000439456/Upstream/30713; ENST00000482165/Downstream/18711;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/2765, chr10-CpG: 34/Downstream/54526
Upstream sequence
TGAGTGATTCCATTAGGTCAGGTTCACAGTCTCAGAGAGACGGCTTCTTGGGTTCTTGTGCTGTTGAAAAGCGTCTCTCTCAGCGTGCTCCTCAGGTGAT
Downstream sequence
GACCTTGTGTTTTGCCATCTTGGTTACAGGGCACGACCAGGAGTTGACGCACTGCTGCACACACCCCACCCAGCGGCTCGTGGTGACCTCCTCCCGTGAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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