Basic Information
VIS ID
TVIS44023077
Fusion event
HTLV-1-VTI1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
114297841/112538082 (Hg38)
End
114297841/112538082 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
VTI1A
miRNAs that regulate target gene
hsa-mir-18a-3p ; hsa-mir-18b-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-6891-3p ; hsa-mir-452-3p ; hsa-mir-5581-5p ; hsa-mir-4297 ; hsa-mir-302a-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-205-5p ; hsa-mir-6793-3p ; hsa-mir-532-5p ; hsa-mir-141-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-107/Upstream/238392; hsa-mir-202/Downstream/96088;
Nearest TSS
ENST00000439456/Upstream/90723; ENST00000346198/Downstream/139737;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/90520, chr10-CpG: 34/Downstream/411808
Upstream sequence
GTATTTTGAAGTAAGATTCATTGTGGCCACATACAACACGAGTCTCCTTTTAAAAACACGAAGTGGATGGTCCATACGTGATTGCTGGAAATCTGTCTAT
Downstream sequence
GGTAGTGGTTCCTATAATGGAAAATTTGCTAAAAATTAACTGTAATGGGTTGCGAACCCCCCCACCCCATGTTAGGGCATACGAAGGCATTTTTTTTTTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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