Basic Information
VIS ID
TVIS44023097
Fusion event
HTLV-1-FRMD4A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p13
Reference genome
GRCh37/hg19
Start
14164057/14122058 (Hg38)
End
14164057/14122058 (Hg38)
Orient
+
Location type
Intronic
Target gene
FRMD4A
miRNAs that regulate target gene
hsa-mir-423-3p ; hsa-mir-218-5p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-3155a/Upstream/1396705; hsa-mir-107/Downstream/261142;
Nearest TSS
ENST00000439456/Upstream/47774; ENST00000443282/Downstream/208826;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/229874, chr10-CpG: 135/Downstream/481695
Upstream sequence
caagatatggaaagcctgtgtctggcacagaatGGTTTTCTACTAGCATTAGCTAGTGCTGTTACACTATtagaaagtgcacctgtagatgttagagaga
Downstream sequence
cttaggttctaactttagctcatcccctaacaacgctgtctctgagcaaattacctaacctctctaagctgcattgtctccatttgttaaatggaaatca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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