Basic Information
VIS ID
TVIS44023111
Fusion event
HTLV-1-DIP2C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p15.3
Reference genome
GRCh37/hg19
Start
320351/274411 (Hg38)
End
320351/274411 (Hg38)
Orient
+
Location type
UTR3
Target gene
DIP2C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-375 ; hsa-mir-545-3p ; hsa-mir-505-3p ; hsa-mir-552-5p ; hsa-mir-302c-5p ; hsa-mir-3529-3p ; hsa-mir-34a-3p ; hsa-mir-1281 ; hsa-mir-6881-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-6852-3p ; hsa-mir-3909 ; hsa-mir-6770-5p ; hsa-mir-1253 ; hsa-mir-4677-3p ; hsa-mir-1236-3p ; hsa-mir-877-3p ; hsa-mir-660-3p ; hsa-mir-5193
Nearest miRNA
hsa-mir-107/Downstream/367278;
Nearest TSS
ENST00000439456/Upstream/29940; ENST00000425723/Downstream/55115;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/137899, chr10-CpG: 32/Downstream/26153
Upstream sequence
CATTTTTCAAAGTATGATTATCTGTACTAAGTAATGCAACAAATTATGTAAACAGAGTCAGATACATTTCCCTGTAGGAGTCACTTCCTTCCCGGGATTA
Downstream sequence
AAGCTGTCCCAGACATCTTTCCAGGGGACCAATTAAGAAACTGCTATTTTCAGAGCAACAAAAATAAAAGCTTTTATTTGTTCATTTGAATATAAAACAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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