Basic Information
VIS ID
TVIS44023117
Fusion event
HTLV-1-CCNY integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
35590197/35301269 (Hg38)
End
35590197/35301269 (Hg38)
Orient
+
Location type
Intronic
Target gene
CCNY
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-let-7b-5p ; hsa-mir-744-5p ; hsa-mir-93-3p ; hsa-mir-193b-3p ; hsa-mir-4669 ; hsa-mir-6516-5p ; hsa-mir-6751-5p ; hsa-mir-6803-5p ; hsa-mir-455-3p ; hsa-mir-4497 ; hsa-mir-4472 ; hsa-mir-4447 ; hsa-mir-7110-5p ; hsa-mir-6842-5p ; hsa-mir-6752-5p ; hsa-mir-6499-3p ; hsa-mir-6835-5p ; hsa-mir-1233-3p ; hsa-mir-1225-3p ; hsa-mir-4795-5p ; hsa-mir-1296-3p ; hsa-mir-298 ; hsa-mir-4696 ; hsa-mir-1252-5p ; hsa-mir-186-3p ; hsa-mir-922 ; hsa-mir-4733-5p ; hsa-mir-3613-3p
Nearest miRNA
hsa-mir-1265/Upstream/221589; hsa-mir-107/Downstream/339903;
Nearest TSS
ENST00000439456/Upstream/54220; ENST00000470025/Downstream/19729;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/86176, chr10-CpG: 141/Downstream/34852
Upstream sequence
gataatctggcaccagggctgagatcttaactacAACATATATTAGCTTTCGGAGCTATTTTTGCCTAAATACAAGCATAATATTCCTTGTTTAACAAAT
Downstream sequence
ATATGGCCAATGTGTGTAGACATGATGGAAGGTCCAGTTTTGAATATGGGTTGAAATGTGTTATCTATTTCCATTAACACTAGAAAGAGTTGTCTGAGAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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