Basic Information
VIS ID
TVIS44023122
Fusion event
HTLV-1-ZNF248 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
38092211/37803283 (Hg38)
End
38092211/37803283 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZNF248
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-1226-3p ; hsa-mir-29b-2-5p ; hsa-mir-4311 ; hsa-mir-515-5p ; hsa-mir-519d-5p ; hsa-mir-519e-5p ; hsa-mir-5695 ; hsa-mir-629-3p ; hsa-mir-634
Nearest miRNA
hsa-mir-1265/Upstream/2162031; hsa-mir-107/Downstream/5194280;
Nearest TSS
ENST00000439456/Upstream/11703; ENST00000429214/Downstream/34828;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/22265, chr10-CpG: 68/Downstream/54291
Upstream sequence
TCTAGGCCCATTTTTTGACCTTTATACAACACTGTCACTTGATTTTTGTAACATCAGAATAGGAACAATGATGCATCTCCACAGGCTGCAAAGACAGTGA
Downstream sequence
GTAGACAGGAAGGGAGCAGGCTTATGGAGGAGCACAGGGACAAGTTCCCCATCTAGGCGATGCCTTCCCCAGACTGTGTCCTCACAGTCCTCACAGTGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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