Basic Information
VIS ID
TVIS44023131
Fusion event
HTLV-1-ANXA8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
49066478/47669159 (Hg38)
End
49066478/47669159 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
ANXA8
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-1265/Upstream/2505071; hsa-mir-107/Downstream/1316353;
Nearest TSS
ENST00000439456/Upstream/69329; ENST00000576178/Downstream/93548;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/103109, chr10-CpG: 39/Downstream/36661
Upstream sequence
tttcattaagcctcccccgcaccaatgtgctttatgtttccctgctctgaaatcctcctgagggaataatcctctagaattttgccttggtgggaaatgc
Downstream sequence
atagtaacctaaccatgtggtatttaggaaggtactgagagattgagcgtttcctaaggagctttcagccagccttctttatttagtgctcccttcacac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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