Basic Information
VIS ID
TVIS44023132
Fusion event
HTLV-1-ANXA8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
49025404/47626430 (Hg38)
End
49025404/47626430 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
ANXA8
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-1265/Upstream/2462342; hsa-mir-107/Downstream/1359082;
Nearest TSS
ENST00000439456/Upstream/26600; ENST00000576178/Downstream/136277;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/60380, chr10-CpG: 39/Downstream/79390
Upstream sequence
CGACTTGACAAGAAAGACTGTGAAAACAAAACCACTATTATCTGTGAACTACCTAATGTGGAAAGAAATATCCTTAAATAAAACTTTGAGAAAGTAGATT
Downstream sequence
ACTCAATTTTTTCCTACAGATATCCCATATATTGTAACTAATTATAATATTTAATTGAATACAAAATCTTTCTTCTTAAGGAAAGATTTTATTCAGTTTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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