Basic Information
VIS ID
TVIS44023135
Fusion event
HTLV-1-C10orf71 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
50509377/49301332 (Hg38)
End
50509377/49301332 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
C10orf71
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1273e ; hsa-mir-4497 ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-4722-5p ; hsa-mir-2467-3p ; hsa-mir-1827 ; hsa-mir-219b-3p ; hsa-mir-4768-3p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-302f ; hsa-mir-8055 ; hsa-mir-8081 ; hsa-mir-6790-5p ; hsa-mir-4658 ; hsa-mir-4758-5p ; hsa-mir-1238-5p ; hsa-mir-216b-3p ; hsa-mir-603 ; hsa-mir-4649-3p ; hsa-mir-7160-5p
Nearest miRNA
hsa-mir-1265/Upstream/315745; hsa-mir-107/Downstream/1998241;
Nearest TSS
ENST00000439456/Upstream/2058; ENST00000423283/Downstream/94119;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/169199, chr10-CpG: 36/Downstream/24897
Upstream sequence
GGGCACACAGGGCTGCTGCTCCCCAACAGGGTCCATCGAGGCTGGAGTGGATTTTGGTTTTATTTCCATTTGAGAGTTTAAACCTCATTTCACAAAATCC
Downstream sequence
AGCCAGTCCATAGTCTTTATCTCAATCATATGCTTCATTTAGTTAATTGGAAAAATCTCAGACACCCCCTCATTTCTACTTGGTTTCCAAGGGTTGCATG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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