Basic Information
VIS ID
TVIS44023136
Fusion event
HTLV-1-ERCC6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
50686905/49478859 (Hg38)
End
50686905/49478859 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
ERCC6
miRNAs that regulate target gene
hsa-mir-4477a ; hsa-mir-126-5p
Nearest miRNA
hsa-mir-1265/Upstream/493272; hsa-mir-107/Downstream/1820714;
Nearest TSS
ENST00000439456/Upstream/2601; ENST00000374115/Downstream/23263;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/80122, chr10-CpG: 68/Downstream/59729
Upstream sequence
CCTTTAATTATTACTATACAGTTAAACCCTAAAGTAGAGACTTACTGGGTTCTTGACCACCAGCCCTAGGGGAAAAACTGCTTTTGTACAAATCTCTGTT
Downstream sequence
TATGATCTTGTATTCTCCAAAAGCTACAAAGGAACTCTGCAAAGCTGAAGATCAAAAGCTAACTCTGGGGAAAAGCTACAGTGATGGAGCAGCCAGCCAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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