Basic Information
VIS ID
TVIS44023151
Fusion event
HTLV-1-PFKFB3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
6224987/6183024 (Hg38)
End
6224987/6183024 (Hg38)
Orient
+
Location type
Intronic
Target gene
PFKFB3
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-330-3p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-6799-5p ; hsa-mir-7106-5p ; hsa-mir-6775-3p ; hsa-mir-1291 ; hsa-mir-765 ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-3185 ; hsa-mir-6892-3p ; hsa-mir-6840-5p ; hsa-mir-6865-3p ; hsa-mir-149-3p ; hsa-mir-185-5p ; hsa-mir-3150b-3p ; hsa-mir-4306 ; hsa-mir-4644 ; hsa-mir-4728-5p ; hsa-mir-4784 ; hsa-mir-6785-5p ; hsa-mir-6883-5p ; hsa-mir-1271-5p ; hsa-mir-182-5p ; hsa-mir-183-5p ; hsa-mir-3609 ; hsa-mir-548ah-5p ; hsa-mir-548az-5p ; hsa-mir-548t-5p ; hsa-mir-6759-3p ; hsa-mir-6782-3p ; hsa-mir-96-5p
Nearest miRNA
hsa-mir-3155a/Upstream/30747; hsa-mir-107/Downstream/5947736;
Nearest TSS
ENST00000439456/Upstream/19191; ENST00000625260/Downstream/19669;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/18776, chr10-CpG: 297/Downstream/17988
Upstream sequence
GACTATGGGGCCCCACAGACCCACCTGTCGCCACAGGTTGAGAACATGGATGGGGCGGTGCCCAGCACGGTCCCTGGCTCCAGGACACAGTGCACAGCCA
Downstream sequence
CAGCCCATACACGCCCCAGCCCCAAACCTAGGAGACTTGGTCCTTCTGTGTCACACCTCTGTTCTCCCTGGAGTTGCAGGGGATTTTCTCTGGAAACTAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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