Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene628904326237419262672011625805936258649962616602626215146261326062615540626313606263330762587101625880126259681262597657626278106262841362592222625926226262680062627090626221276262230262610762626109316259412262594271626115846261169362632312
Basic Information
VIS ID
TVIS44023152
Fusion event
HTLV-1-ZNF365 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
64392072/62632312 (Hg38)
End
64392072/62632312 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
ZNF365
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-7-5p ; hsa-mir-223-3p
Nearest miRNA
hsa-mir-1265/Upstream/5327753; hsa-mir-107/Downstream/740645;
Nearest TSS
ENST00000439456/Upstream/111864; ENST00000461412/Downstream/11461;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/257651, chr10-CpG: 152/Downstream/172363
Upstream sequence
actccccagcccctgctctttccactgtgtcatactCTTGGCCACTTCCTGTCTTGCTTGAACAAACATAGTTCAGGCAAAACGTACAAGCAACGATGAC
Downstream sequence
GTGCCACTGTTACACCTCCCAATTAAAACCTATAATTTCCGAGTCTGAACTGGAAATCCTTTGGCTCTGTGCTTTTGTCTGGCCTGCTCAGGAAAATGTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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