Basic Information
VIS ID
TVIS44023157
Fusion event
HTLV-1-CTNNA3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
68912301/67152543 (Hg38)
End
68912301/67152543 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
CTNNA3
miRNAs that regulate target gene
hsa-mir-182-5p ; hsa-mir-5704 ; hsa-mir-4470 ; hsa-mir-3065-5p ; hsa-mir-3613-3p ; hsa-mir-1295b-3p ; hsa-mir-15a-3p ; hsa-mir-4717-5p ; hsa-mir-6826-3p ; hsa-mir-6891-3p ; hsa-mir-6072 ; hsa-mir-6795-3p ; hsa-mir-6887-3p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548as-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p
Nearest miRNA
hsa-mir-1265/Upstream/3779495; hsa-mir-107/Downstream/250808;
Nearest TSS
ENST00000439456/Upstream/99934; ENST00000610279/Downstream/27900;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/2098240, chr10-CpG: 39/Downstream/611542
Nearest cancer related gene
CTNNA3(TSG, No orient, 0)
Upstream sequence
TACGTTTAGTGTCATAATTAGTAATCTATAAATGTGGATTTATTTCATAATGCAATTAGATGAAATGCATATAAAGATGGTGACTTATGAAATGACAAAG
Downstream sequence
AATTCTAAAGCTTATCATAAAACTTAAGCATTTTCAAATGAATAATAAATGGCCATATTCATCAATGCCTCCCAGTATTATAATTACACATTTTTAATTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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