Basic Information
VIS ID
TVIS44023158
Fusion event
HTLV-1-TET1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
70429825/68670068 (Hg38)
End
70429825/68670068 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
TET1
miRNAs that regulate target gene
hsa-mir-29b-3p ; hsa-mir-29a-3p ; hsa-mir-21-5p ; hsa-mir-877-5p ; hsa-mir-454-3p ; hsa-mir-141-3p ; hsa-mir-576-5p ; hsa-mir-3686 ; hsa-mir-4263 ; hsa-mir-4735-5p ; hsa-mir-4778-5p ; hsa-mir-5571-5p ; hsa-mir-1305 ; hsa-mir-421 ; hsa-mir-505-3p ; hsa-mir-7159-5p ; hsa-mir-3065-5p ; hsa-mir-205-3p ; hsa-mir-30a-5p
Nearest miRNA
hsa-mir-1265/Upstream/1266658; hsa-mir-107/Downstream/3120679;
Nearest TSS
ENST00000439456/Upstream/109412; ENST00000494903/Downstream/50944;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/109003, chr10-CpG: 89/Downstream/50879
Upstream sequence
tagattccacaattgttaacactatgttacatttgtttacgtacacatacaaacacgttactgttgtagacttatttctttcttgatcatttgagagcta
Downstream sequence
gatgtagactttgtctttttccctaaataatacttgaatgtatttatcctaaaaatgaggattgttctcttgtatatccccatataatgatcaaattcag
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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