Basic Information
VIS ID
TVIS44023167
Fusion event
HTLV-1-ATP5F1C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p14
Reference genome
GRCh37/hg19
Start
7837947/7795984 (Hg38)
End
7837947/7795984 (Hg38)
Orient
+
Location type
Intronic
Target gene
ATP5F1C
miRNAs that regulate target gene
hsa-mir-30b-5p ; hsa-mir-16-5p ; hsa-mir-1231 ; hsa-mir-632 ; hsa-mir-4288 ; hsa-mir-3605-5p ; hsa-mir-3679-5p ; hsa-mir-1185-5p ; hsa-mir-3655 ; hsa-mir-7162-3p ; hsa-mir-4649-3p
Nearest miRNA
hsa-mir-3155a/Upstream/1643707; hsa-mir-107/Downstream/4334776;
Nearest TSS
ENST00000439456/Upstream/7774; ENST00000473809/Downstream/4068;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/7430, chr10-CpG: 79/Downstream/22314
Upstream sequence
CTGGGAAGGTGGTGGTACAGACAGGCCAAATAAAAGGAGGCCTTCAATACAGGGATTTGCGCCACTACTAAGGGATTTAAATATATGTCTATTCATATAC
Downstream sequence
ATTCTGAGTCCTGTATTTGATAGATTGTTTCTTTATGGGGTATTCTTTAAATAAATATATATTAACTGAAAGTTTTTCTTGTATAATGGAACTATTTTTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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