Basic Information
VIS ID
TVIS44023176
Fusion event
HTLV-1-BTAF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q23.32
Reference genome
GRCh37/hg19
Start
93687578/91927821 (Hg38)
End
93687578/91927821 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
BTAF1
miRNAs that regulate target gene
hsa-mir-505-3p ; hsa-mir-15b-5p ; hsa-mir-183-5p ; hsa-mir-10a-5p ; hsa-mir-92a-3p ; hsa-mir-16-5p
Nearest miRNA
hsa-mir-107/Upstream/2334994; hsa-mir-1287/Downstream/4136494;
Nearest TSS
ENST00000439456/Upstream/4052; ENST00000476401/Downstream/7331;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/3739, chr10-CpG: 33/Downstream/117934
Upstream sequence
acaattattatttaaattattcacaagaaacactgaaagcctgtaacatatactaatttgttttttgctgaggttgactttgtggaagcaagtcaagtaa
Downstream sequence
ctagtgaatgactagctgactttccagcatccgcatcttagggacaacattgttctctactcCTACATTTGTAGGAGTATGATTTTACCGTAATTTGTGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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