Basic Information
VIS ID
TVIS44023180
Fusion event
HTLV-1-BLNK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
97990662/96230906 (Hg38)
End
97990662/96230906 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
BLNK
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-107/Upstream/166507; hsa-mir-1287/Downstream/597763;
Nearest TSS
ENST00000439456/Upstream/3409; ENST00000630152/Downstream/40492;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/100251, chr10-CpG: 20/Downstream/153636
Nearest cancer related gene
BLNK(TSG, No orient, 0)
Upstream sequence
CACTGCTCCTCTTCGTCAGCAGGGCTCTCTGCAACAGCAGGGGAGAAGCAGAAGGCACAAGTGTGAGCCTCAGCTGGCCAGCCCCAGCCCATCCACACAC
Downstream sequence
ATTTCGCACCTGCCTTCCCTTCCCTTTGGGCTTTCTGGTGCCATATACTTGACCTTGGGTTAGTTACTACAATCATATGTTCACTTGCTTTTGACTTTTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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