Basic Information
VIS ID
TVIS44023182
Fusion event
HTLV-1-CNNM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
101089405/99329648 (Hg38)
End
101089405/99329648 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
CNNM1
miRNAs that regulate target gene
hsa-mir-1915-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-4279 ; hsa-mir-4722-3p ; hsa-mir-4726-3p ; hsa-mir-498 ; hsa-mir-6727-3p ; hsa-mir-6747-3p ; hsa-mir-6764-5p ; hsa-mir-6778-3p ; hsa-mir-6791-3p ; hsa-mir-6829-3p ; hsa-mir-6836-3p ; hsa-mir-6840-3p
Nearest miRNA
hsa-mir-107/Upstream/405080; hsa-mir-1307/Downstream/1645337;
Nearest TSS
ENST00000439456/Upstream/549; ENST00000488090/Downstream/38689;
Nearest CpG islands
chr10-CpG: 133/Target, None/Upstream, None/Downstream
Upstream sequence
CGTGTCCCTGGAGGGGGGCACCCTGCGCGCCGCCGAAGGCACCAGCTTCCTCCTGCGTGTCTATTTCCAGCCAGGACCGCCGGCCACCGCCGCACCGGTG
Downstream sequence
CCCTCACCGACCCTCAACTCGGGGGAGAATGGCACCGGCGACTGGGCTCCGCGGCTCGTGTTCATCGAGGAGCCCCCGGGCGGTGGCGGCGTGGCCCCCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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