Basic Information
VIS ID
TVIS44023189
Fusion event
HTLV-1-NPAT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
108092127/108221400 (Hg38)
End
108092127/108221400 (Hg38)
Orient
-
Location type
Intronic
Target gene
NPAT
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-4772-5p ; hsa-mir-383-5p ; hsa-mir-4765 ; hsa-mir-759 ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-5586-3p ; hsa-mir-3925-5p ; hsa-mir-4773 ; hsa-mir-4797-5p ; hsa-mir-595 ; hsa-mir-4796-3p ; hsa-mir-3609 ; hsa-mir-548ah-5p ; hsa-mir-106a-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p
Nearest miRNA
hsa-mir-10392/Upstream/4371420; hsa-let-7a-2/Downstream/3126357;
Nearest TSS
ENST00000527297/Upstream/51199; ENST00000532931/Downstream/1084;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/99396, chr11-CpG: 75/Downstream/1084
Upstream sequence
tgaggcccaaaatgttaacagtactgaggctgagaaaccatgTTTAAGACTATAGTTACCGAAACTCAACTAGATTACCAAACTGCCAAAACTCAGAATT
Downstream sequence
CTTAAGCAAAAGATTAATCAGACATTAACAAAACATTAAACTTGTCATTAAGTTTCTTCAAAAATGGATGGTGGAACCATTTCCGTTTAACGTTTCCTGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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