Basic Information
VIS ID
TVIS44023194
Fusion event
HTLV-1-SIK2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
111569391/111698667 (Hg38)
End
111569391/111698667 (Hg38)
Orient
-
Location type
Intronic
Target gene
SIK2
miRNAs that regulate target gene
hsa-mir-1229-3p ; hsa-mir-125b-5p ; hsa-mir-181a-5p ; hsa-mir-142-3p ; hsa-mir-218-5p ; hsa-mir-4786-3p ; hsa-mir-575 ; hsa-mir-4676-5p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-3679-3p ; hsa-mir-6873-3p ; hsa-mir-4436b-5p ; hsa-mir-3124-3p ; hsa-mir-6845-3p ; hsa-mir-5698 ; hsa-mir-8057 ; hsa-mir-891a-3p ; hsa-mir-143-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-564 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-2276-3p ; hsa-mir-1304-3p ; hsa-mir-5693 ; hsa-mir-6890-3p ; hsa-mir-4279 ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-6778-3p ; hsa-mir-6789-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-4740-3p ; hsa-mir-4438
Nearest miRNA
hsa-mir-10392/Upstream/185152; hsa-let-7a-2/Downstream/1751356;
Nearest TSS
ENST00000527297/Upstream/96276; ENST00000533868/Downstream/20075;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/95452, chr11-CpG: 60/Downstream/67203
Upstream sequence
cctgtctctactaaaaatacaaaaattagcctggtgtggtggagcacacctgtgctactcaggaggttgaggtgcgaggactgcagtgagctgagatcgt
Downstream sequence
gccattgcactctagcctgggcaacagagcaagaccctatctcaaaaaagaaaagaaagaaagaaaaaCAACCTTACCAGTGCTATTTGGAGAGTATCCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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