Basic Information
VIS ID
TVIS44023197
Fusion event
HTLV-1-NCAM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
113038618/113167896 (Hg38)
End
113038618/113167896 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11G
Target gene
NCAM1
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-210-3p ; hsa-mir-200c-3p ; hsa-mir-375 ; hsa-mir-30a-5p ; hsa-mir-3148 ; hsa-mir-651-3p
Nearest miRNA
hsa-mir-10392/Upstream/1654381; hsa-let-7a-2/Downstream/282127;
Nearest TSS
ENST00000527297/Upstream/34968; ENST00000534046/Downstream/63484;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/204128, chr11-CpG: 34/Downstream/146714
Upstream sequence
GCGGACTTTTCTAGAATGGATCCAGTGTGACCAGTTTGCTGTGGCTTCATAATAGCAAGCGAGATGGCGGTTGGGCAGGGTGTATTACTGTTGTTGTTGT
Downstream sequence
TTTTGTCCGACAGCTTGGTTTTCTCTTCTCTCCCCAAAAAGTTGATCCACATCTTTACATACCTGTTCTATAACTTCTTTGGAAACTGTATGTATGTTAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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