Basic Information
VIS ID
TVIS44023199
Fusion event
HTLV-1-SIK3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
116797753/116927037 (Hg38)
End
116797753/116927037 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11G ; FRA11B
Target gene
SIK3
miRNAs that regulate target gene
hsa-mir-454-3p ; hsa-mir-620 ; hsa-mir-1270 ; hsa-mir-4683 ; hsa-mir-501-5p ; hsa-mir-500a-5p ; hsa-mir-6083 ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-466 ; hsa-mir-3941 ; hsa-mir-656-3p ; hsa-mir-5011-5p ; hsa-mir-410-3p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-1277-5p
Nearest miRNA
hsa-mir-10392/Upstream/3476949; hsa-let-7a-2/Downstream/1716963;
Nearest TSS
ENST00000527297/Upstream/51524; ENST00000442124/Downstream/30007;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/90843, chr11-CpG: 117/Downstream/170785
Upstream sequence
ttgaacctgggagatggaggctgcagtgagtcaagactgcaccactgcactccagcctgggcgacaatgagactcagtctcgaaaaaaaaaaaaaaaGGG
Downstream sequence
CAGGGGAGGGGAAGTACTTTTAAAGTTTATCAATTTTCAGGCTATTTTTTTTTTCATCTTAAATTGTCCTTACTTTCACAATAGTTCTTTCTGAAGAGAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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