Basic Information
VIS ID
TVIS44023215
Fusion event
HTLV-1-PARVA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.3
Reference genome
GRCh37/hg19
Start
12537048/12515501 (Hg38)
End
12537048/12515501 (Hg38)
Orient
+
Location type
Intronic
Target gene
PARVA
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-633 ; hsa-mir-3160-5p ; hsa-mir-631 ; hsa-mir-3661 ; hsa-mir-1322 ; hsa-mir-1272 ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-4485-5p ; hsa-mir-483-3p ; hsa-mir-5195-5p ; hsa-mir-24-1-5p ; hsa-mir-24-2-5p ; hsa-mir-888-5p
Nearest miRNA
hsa-mir-210/Upstream/351734; hsa-let-7a-2/Downstream/3454032;
Nearest TSS
ENST00000527297/Upstream/41757; ENST00000527376/Downstream/25466;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/137185, chr11-CpG: 178/Downstream/158366
Upstream sequence
GGAATGTTCTGGAAAAGTGACGCTTCCTTGAGTGAGCTAGAATGGGCCCTGGAATGATCAGCTCCGTTTTCAAGGGCAGGGAGTGCTATGACAGGGGTCA
Downstream sequence
CTGCCAAGCACTTTGGGTCTCTACAGTTTTATCTACTATTCCTACCAAGTCAGTGGAACCAGCCATGGGAGGTGAGGAGCAGTCTAAGCCTGGCACTCAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate